Neuronal (Paraneoplastic) Autoantibodies Profile Ultra Test Cost & Procedure

Beneficial in the Early determination of underlying cancer and prompt beginning of treatments.

This analysis determines antibodies against neuronal antigens in Paraneoplastic syndromes. It is utilized in the determination of Paraneoplastic neurological autoimmune disease correlates the d to tumors of the lung, breast, ovary, Thymoma, and Hodgkin lymphoma.

Antibodies

Antibodies are immunoglobulins that are formed by the body against invading foreign substances, these foreign substances are antigens. When antibodies act against the body’s cells are called autoantibodies.

Paraneoplastic test

It is used to diagnose the neuronal paraneoplastic syndrome.

Paraneoplastic syndrome

It is a group of disorders that are caused by abnormal autoimmune responses in which antibodies attack normal cells of the nervous system. These disorders reflect a patient’s immune response against cancer that is due to the remote effects of malignant tumors.

Commonly affected age groups

It is prevalent in middle-aged or older persons.

Symptoms of the paraneoplastic syndrome

• Difficulty in walking
• Dysphagia
• Seizures
• Hypotonia
• Ataxia
• Slurring of speech
• Memory loss
• Vision problems
• Sensory loss in the limbs
• Difficulties in sleep
• Vertigo

Paraneoplastic syndromes include

• Stiff-Person Syndrome
• Opsoclonus
• Encephalomyelitis
• Lambert-Eaton Myasthenic Syndrome
• Cerebellar Degeneration
• Brainstem Encephalitis
• Neuromyotonia
• Sensory Neuropathy
• Myasthenia gravis

Pathophysiology of the paraneoplastic syndrome

In this body forms antibodies to eliminate tumor cells from the body but these antibodies attack normal neuronal cells and tissues.

Why paraneoplastic antibody test

• To differentiate autoimmune neurological disordersmonthnthe iresponsesponsof the seropositivetivee patient
• To detect early evidence of cancer reoccurrence

Components of neuronal antibody profile test

It is used to determine auto-antibodies against 12 different antigens which are:

• CV2-positive in small cell lung cancer
• PNMA2 (Ma2/Ta)-positive in seminoma
• Amphiphysin-positive in breast
• Recoverin- small cell lung cancer
• SOX1- small cell lung cancer
• Hu-positive in small cell lung cancer or neuroblastoma
• Titin-thymoma
• GAD65- small cell lung cancer/breast cancer/colon cancer
• Yo-positive in ovary/breast cancer or uterine cancer
• Tr (DNER)-Hodgkin’s Lymphoma
• Ri-positive in small cell lung cancer or breast cancer
• Anti Zic4

Treatment of paraneoplastic syndrome

Plasmapheresis- it is a process used to clear out antibodies from blood to provide relief from symptoms.

• Speech and physical therapy
• IImmunosuppressantscan also is used.