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A genetic test for TP53 looks for an alteration, or mutation, in the TP53 gene (tumor protein 53). The fundamental elements of heredity that come from your mother and father are called genes. A gene called TP53 aids in slowing the development of cancers. It has the label "tumor suppressor."
a gene that produces a protein that is essential for regulating cell division and death and is located inside the nucleus of cells. The TP53 gene may have mutations (changes) that cause cancer cells to multiply and spread throughout the body.
Given the high risk of childhood cancers that persists throughout a person's life, patients begin having frequent screenings as infants to look for signs of disease.
The tumor-suppressing protein p53 also referred to as the genome's guardian shields our cells from cellular harm. When cells are under stress, the protein p53 springs into action and controls gene expression to regulate DNA repair, cell division, and cell death.
Researchers have been researching the role of TP53 mutations, which are common prognostic indicators, in the prognosis of patients with LUAD. In NSCLC, the clinical response to a combination of anti-CTLA-4 and anti-PD-(L)1 treatment can be predicted by TP53 mutations (Hellmann et al., 2018b)
The TP53 gene, which spans 11 exons and about 20 000 bp of a genomic sequence, is found on the long arm of chromosome 17. A 53 kDa nuclear phosphoprotein with 393 amino acid residues is produced by the gene.
There are currently no cancer therapies authorized especially for patients with a TP53 mutation. However, because radiation exposure raises the risk of receiving a new cancer diagnosis, recommendations do urge those with a hereditary TP53 mutation to reduce it.
393 amino acids make the phosphoprotein known as p53. It is made up of four components (or domains): a region that makes transcription factors active. a domain that can identify particular DNA sequences (core domain).
The p53 gene is typically altered, producing a stable mutant protein whose accumulation is thought to be a characteristic of cancer cells. In addition to losing their tumor-suppressing properties, mutant p53 proteins frequently acquire new oncogenic properties that provide cancer cells an edge in terms of proliferation and survival.
By stopping the cell cycle to give the repair mechanisms time to restore genomic stability, p53 plays a significant function as a DNA repair facilitator. Additionally, p53 adopted a variety of roles to directly influence the operation of different DNA-repair mechanisms.
Test Type | TP53 Sequencing |
Includes | TP53 Sequencing (Pathology Test) |
Preparation | |
Reporting | Within 24 hours* |
Test Price |
₹ 26250
|
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