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KRAS pathway is involved in the initiation of a number of pathways, which regulate cell growth, cell division, cell survival, and cell death.
KRAS is the most common proto-oncogene. The highest rate of mutation among all cancers is of KRAS gene.
It is seen that the KRAS is mutated in about 15% to 20% of human cancers, mostly seen in pancreatic cancer, the colon cancer and in lung cancers as well as in leukemia.
In approximately 30% to 40% of the colon cancers and about 15% to 30% of the lung cancers might have KRAS mutations.
Currently, it must be noted that the drugs that target the EGFR and are used to treat colon cancer and non-small cell lung cancer.
KRAS mutation testing will be used to determine whether these corresponding drugs would be effective in treating these cancers successfully.
When the patient has colon cancer that has spread to different parts of the body (metastatic) or in case of non-small cell lung cancer.
Following samples are collected for KRAS mutation PCR:
KRAS mutation transcripts are identified in the laboratory using a Real Time PCR machine, operated by a skilled technician. 22 different mutations in it .It is seen that the KRAS gene can be identified in a single run itself.
There is no specific preparation required for KRAS mutation PCR. Let your healthcare professional know about the following:
This test is useful in the detection of the specific mutations in the KRAS gene in DNA of cancer cells and the tissue.
The presence of these mutations might further indicate that there are certain drugs that would not be effective in treating the cancer.
KRAS is a short form for the gene: Kirsten rat sarcoma viral
Note: The research has evaluated the role of the KRAS mutations in treatment response. It has been to be based solely on tumor testing.
Therefore, the preferred sample for the KRAS testing is considered to be tumor tissue even though blood tests may be conducted
Usually, the testing is performed on tumor tissue removed from the patient during a previous surgery or biopsy procedure. Typically, patients undergoing KRAS testing are those with high-stage tumors that require adjuvant therapy.
Detect mononuclear cells in the bone marrow sample, if KRAS mutation gene is present in the patient’s body.
The cost of this test varies from lab to lab. The best place to get this test done is Ganesh Diagnostic and Imaging Centre. The cost is reasonable and you can also avail FLAT 50% discount.
INR 12000 INR 6000
| Test Type | KRAS Mutation Detection |
| Includes | |
| Preparation | There is no specific preparation required for KRAS mutation PCR. Let your healthcare professional know about the following:
|
| Reporting | Within 24 hours of sample collection |
| Test Price |
₹ 6000
|
KRAS mutations are detected in the following types of cancers:
There is no risk associated with non-invasive sample collection such as blood sample. In case, biopsy of tissue is required, your doctor will let you know about the procedure.
It means that you have a spontaneous mutation in KRAS gene. This is an indication towards uncontrolled cell growth and division in the body. The mutation occurs in somatic cells.
FDA approved drug Sotorasib is used for treating NSCLC.
Early check ups are always better than delayed ones. Safety, precaution & care is depicted from the several health checkups. Here, we present simple & comprehensive health packages for any kind of testing to ensure the early prescribed treatment to safeguard your health.
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