IHC: Ki-67 Marker Test Cost & Procedure

The nuclear protein Ki-67 is essential for preserving cell growth. All non-G0 stages of the cell cycle contain Ki-67. The level rises mid-G1 and continues through S and G2 to peak in the M phase. It quickly metabolised at the end of the M phase. In many different forms of neoplasms, including malignant lymphomas, prostatic and breast adenocarcinomas, astrocyte neoplasms, and soft tissue neoplasms, Ki-67 has been used as a marker of proliferation and, consequently, prognosis.

What is The IHC - Ki67 Marker?

Additionally, it aids in classifying neuroendocrine cancers. This tesevaluateste the growth of tumor cells in all cancer types. Nuclear non-histone protein Ki-67 is found in increasing cells at higher levels than in quiescent cells. Because of this, the IHC (Immunohistochemical) Method refers to Ki-67 as a specific nuclear marker for cell proliferation.

IHC - Ki67 Marker Test Preparation

For this test, no extra preparation is required. Before having the IHC-Ki-67-Marker, let your doctor know if you use any prescription drugs, have any underlying medical conditions, or have any allergies. Your doctor will provide particular instructions based on your requirements.

IHC - Ki 67 Marker Test Applications

Since Ki-67 is a nuclear non-histone protein, quiescent cells have low levels of i,t, while proliferating cells have higher levels. Hence, it is a particular atomic marker for cell proliferation. A higher Ki-67 reactivity may indicate unfavorable results if the Ki-67 value for breast cancer is increased. The prognosis is favorable.

IHC - Ki 67 Marker Test Procedure:

• A smear or a piece of tumor tissue is obtained as the sample.
• To prevent them, an example, from becoming contaminated, caution must be exercised.
•  The tumor tissue that has been collected isdeparaffinisedd, and then the antigen is revealed.
• Utilizing chromogens results in staining. It is recorded and analysed how many tumor cells exhibit nuclear staining.