Hepatitis B Envelope Antigen (HbeAg) Quantitative Test and Its Cost in Delhi, India

The hepatitis B virus leads to hepatic infection. It is a crucial problem for global health. It considerably raises the risk of cirrhosis and mortality from liver cancer, can result in persistent infection, and Hepatitis B virus transmission.

Transmission of hepatitis B

Among other processes, HB infection of the placenta, disruption to the placental barrier, and hematogenous blood transfusions all contribute to HB intrauterine transmission. The placenta can transmit HB from cell to cell by transcytosis, or a preterm birth can cause a placental leak. HB infection in the mother's morphonuclear cells results in additional pathways that can spread to the baby's circulation. An immunohistochemistry analysis of all maternal placental cells showed that HB can infect placental cells.

An increased risk of placental HB infection was discovered to be associated with higher HBsAg titers. The likelihood of intrauterine HB infection is most frequently associated with HB infection in trophoblasts near the villi capillary. Peripheral polymorphonuclear cells (PMNs), which are blood cells that can be infected by HBV and act as both reservoirs and sites for extrahepatic viral replication. This cell has the potential to transmit HB to the foetus by entering the foetal blood circulation.

HbeAg Quantitative test

The quantitative test is associated with detection of hepatitis b antigen and hepatitis b antibody.

Hepatitis B virus (HBV) DNA polymerase enzyme and Dane particles are both linked to the presence of HBeAg in serum. These indicators point to ongoing HBV replication. People who have the hepatitis B surface antigen (HBsAg) or the hepatitis B epitope antigen (HBeAg) are much more likely to spread infections to others. During hepatitis B Anti-HBe production is a sign of healing.

The main tool for deciding which individuals to treat, gauging their response to treatment, and spotting antiviral drug resistance is HBV DNA measurement. Recent research has demonstrated the use of quantitative HBsAg to categorise patients, predict the effectiveness of antiviral medication, and create a new function for blood HBsAg in clinical practice.

Numerous studies have measured the baseline and ongoing treatment HBsAg titres in order to predict the antiviral treatment outcome using various criteria.The levels of intrahepatic covalently closed circular DNA (cccDNA)17, 21 and serum HBV DNA have been positively correlated in some studies.This sparked interest in measuring serum HBsAg serology levels. HBsAg measurement was more affordable, fully automated, and had a higher output capacity than HBV DNA quantification.