Ganglioside (GM1) IgM Antibody Panel Test Cost & Procedure

Patients with neuropathy may have a variety of sensory disturbances, including loss of or heightened pain sensations, as well as weakness and autonomic involvement (sweat abnormalities, gastrointestinal dysfunction, and lightheadedness on standing).

Gangiolsides are glycosphingo lipids that include sialic acids and are found in many different cell types, though they are particularly prevalent along the linings of brain tissues.

An autoimmune neuropathy is diagnosed using the test mentioned above.

What are gangliosides?

• A particular class of glycosphingolipids called gangliosides is present in the cell membrane of vertebrate neurons.
• These glycolipids target ganglioside IgM antibodies which can result in neurological illnesses like iller-Fisher syndrome, sensory neuropathy, and multifocal Guillain-Barré syndrome.
• In an autoimmune attack on the nervous system, IgM antibodies—the first to be produced—are measured as part of the test. Various ganglioside IgM antibodies, including GM1, GM2, GM3, GD1a, GD1b, GQ1b, and GT1b, can be found using the test.
• Certain neurological illnesses can be diagnosed, and their progression can be tracked using tests to see if these antibodies are present in the serum.

Why is IgM Antibody Test for Ganglioside Conducted?

• To determine the existence of autoimmune neurological conditions, including Miller-Fisher syndrome, Guillain-Barré syndrome, and chronic inflammatory demyelinating polyneuropathy (CIDP). To assess the likelihood of autoimmune neurological disorders emerging in people with a history of the condition or exposed to specific environmental variables.
• To rule out other illnesses, such as infections or metabolic abnormalities, which may have symptoms similar to those of autoimmune neurological disorders.
• It can help identify neurological illnesses with comparable clinical manifestations.
• To Confirmation of a clinically symptomatic and other laboratory-based autoimmune neurological disease that is suspected to exist.

What is measured by the test for ganglioside IgM antibodies in serum?

The Ganglioside IgM Antibody Serum Test quantifies ganglioside-specific IgM antibody levels.

What happens if the Ganglioside IgM Antibody Serum test yields impressive results?

The presence of ganglioside IgM antibodies in the serum is frequently a sign of a nervous system-specific autoimmune disease.