FISH, Prenatal Aneuploidy Detection-CVS (5 Probes- Trisomy 21,18,13; X,Y) Test Cost & Procedure

Valuable for

Evaluating  prenatal instances for chromosomal aneuploidies of chromosomes

Experimenting procedure

The first probe set (2 FISH probes) application and expert interpretation of the results are included in the cost of this test.

All reflex probes that are carried out will incur additional fees. The cost of the analysis will depend on how many cells are examined by each probe set. No charges for analysis will be made if there are no cells available.

Particular Instructions

Educated Consent for Genetic Experimenting

Scholarly Consent for Genetic Experimenting

Method Name

Fluorescence In Situ Hybridization (FISH)

Reporting Name

Prenatal Aneuploidy Detection, FISH

Specimen Type

Varies

Specimen Required

Ordering Instructions

Other than 13, 18, 21, X, or Y chromosomes, this test is unable to identify aneuploidy. Other structural or chromosomal abnormalities cannot be found using this test.

This method might not pick up on minor mosaicism involving chromosomes 13, 18, 21, X, or Y.

Important Information

Each specimen should include the gestational age and the reason it was referred, and the specimen source should be confirmed. If this news is not replenished, the lab will not rescind the examination, but precise experimenting and interpretation may be hindered or postponed.

Sample Required

Only 1 of the following specimens should be submitted:

Preferred:

Materials: 5 lb. Refrigerate/Ambient Mailer (T329)

Type of Specimen: Amniotic fluid

A tube or container for amniotic fluid

Sample Volume: 20 to 25 mL

Instructions for Collection:

1. Although specimens collected at other weeks of gestation are also acceptable, the best time to collect specimens is between 14 and 18 weeks of pregnancy. The date of amniocentesis and stational age should be provided.

2. Fling out the initial two mL of amniotic liquid.

3. Insert the tubes into a 5-pound Refrigerate/Ambient Mailer (T329).

4. Packing material should be placed in the space.

Additional Details:

1. Acceptable:

Supplies: Small Dish and CVS Media (RPMI) (T095)

Type of Specimen: Chorionic Villi

15-mL tube with 15 mL of transport fluid inside of it

Sample Size: 20–30 mg

Instructions for Collection:

1. Use the transabdominal or transcervical method to collect the specimen.

2. Spot the chorionic villi in a Petri container with carrier media, such as CVS Media.

3. Examine the villi's quantity and quality using a stereomicroscope and sterile forceps, and eliminate any blood clots and maternal decidua

Standard chromosomal analysis and FISH are two methods to identify aneuploidy. It takes 5 to 9 days to culture, extract, and analyze chromosomes from chorionic villi or amniotic fluid cells, according to standard procedures.