Colaris Test Cost & Procedure

A person's chance of acquiring hereditary colorectal cancer and uterine cancer in women is determined by the genetic test COLARIS.

Why is this test suggested?

According to estimates, 3% to 5% of all colorectal malignancies are caused by Lynch syndrome, the most common hereditary colon cancer condition, also known as Hereditary Nonpolyposis Colorectal Cancer (HNPCC). Understanding the outcomes may enable patients and their doctors to take proactive measures to stop cancer before it can spread. Mutations in the mutY homolog (MYH) gene lead to MYH-associated polyposis (MAP). Biallelic MYH mutations—mutations in both MYH genes, one from each parent—are present in people with MAP. An essential component of the base is the MYH gene.

What Is Colon Cancer?

The cells that line the colon or the rectum can develop abnormalities and out-of-control growth to cause colorectal cancer, also known as cancer of the large intestine.

Adenomatous polyps, tiny, noncancerous (benign) clusters of cells, are the precursors to most colorectal cancer cases. Some of these polyps could eventually develop into cancer. Polyps and colon cancer can be seen during a colonoscopy.

Hereditary colorectal cancer may be suspected if symptoms appear before age 50, a person develops more than one primary malignancy, or if numerous family members are affected. Both individuals with polyposis and those without polyposis of the colon should undergo this test. This testing may be suitable for some paediatric patients after considering the patient's clinical and family history. This test is intended to identify people who have a germline pathogenic variation, and it has not been proven to identify mosaicism below a 20% level. On tumour tissue, it shouldn't be requested.

These testing can be categorised into two categories:

Tests that examine the stool (or faeces) look for indications of malignancy. These tests require more frequent administration despite being less intrusive and easier to perform.

Visual (structural) examinations: These tests look at the colon and rectum's structure to look for any abnormal spots. Both a scope—a tube-like tool with a light and tiny video camera on the end

COLARIS Testing Advantages:

The COLARIS test results allow for creating a patient-specific medical care roadmap that drastically lowers cancer risk. COLARIS can assist you in: Individualize patient care and boosting clinical effectiveness by focusing greater surveillance and other therapies specifically on those with Lynch Syndrome or MYH-associated polyposis (MAP) mutations. Screening advice and preventive interventions will increase patient compliance.

Improve health outcomes and cut expenses by preventing cancer and quickly diagnosing and treating it if it arises. The primary factor that led to cancer in their families should be disclosed to patients and their family members.

• Breast Cancer (Lynch syndrome and MAP)
• increased colorectal cancer surveillance
• Treatment of colorectal cancer with surgery Ovarian and Endometrial Cancer (Lynch syndrome)