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A blood examination named the c-KIT gene mutation examination is utilized to find disorders like melanoma, acute myeloid leukemia, and gastrointestinal stromal tumors. GISTs, or gastrointestinal stromal tumors, are cancers that evolve in the digestive system. These are typically located in the small intestine or the stomach. This test is effective at identifying KIT gene mutations or alterations because they are frequently linked to gastrointestinal cancers.
One of the most effective diagnostics for identifying GISTs is the c-KIT gene mutation test. It is important to notify your doctor right once if you experience any GIST symptoms, such as stomach pain, loss of appetite, or blood in your stools or vomit. This facilitates early tumor detection and initiates treatment.
To discover modifications and determine several disorders, including leukemia, unilateral ovarian dysgerminoma, and others.
Hematopoietic stem cells and other cell types express the cytokine receptor KIT on their surface. Some cancer types may be related to altered versions of this receptor. Stem cell factor commonly referred to as "steel factor" or "c-kit ligand," is a receptor tyrosine kinase type III that interacts with KIT. The stem cell aspect turns on this receptor's intrinsic tyrosine kinase activity, which in turn phosphorylates and transmits signal transduction element that circulates the signal throughout the cell. The receptor is ubiquitinated after activation, designating it for delivery to a lysosome and eventual death.
The diverse mechanisms that donate to the growth of tumors and the growth of carcinomas are remarkably regulated by c-KIT. In several malignancies, c-KIT has been suggested as a stemness regulator. With-it prostate cancer cells, non-small cell lung cancer cells, ovarian cancer cells, and colon cancer cells, its manifestation has existed related to cancer stemness. Also, the epithelial-mesenchymal transition (EMT), which affects tumor aggressiveness and metastatic potential, has been connected to c-KIT.
In immunohistochemistry, antibodies to KIT are frequently used to differentiate certain tumor types in histological tissue sections. It is largely used to diagnose GISTs, which are KIT-positive but lack certain markers.
Test Type | C-KIT Gene Modification (4 Exons) |
Includes | C-KIT Gene Modification (4 Exons) (Pathology Test) |
Preparation | |
Reporting | Within 24 hours* |
Test Price |
₹ 4350
|
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