AML Multiplex Basic Reflex to FLT3-ITD Allelic Ratio Test Cost & Procedure

The flt3 mutation is what?

In leukaemia (blood cancer) cells, there is a gene alteration, or mutation, called FLT3. AML, a form of leukaemia that begins in the bone marrow and frequently spreads into the blood, has this genetic mutation the most frequently.

The FLT3 gene encodes a protein that aids in the development of white blood cells. Too many aberrant white blood cells can form when this gene is altered.

This mutation comes in two different forms:

Multiple gene copies in a row are called FLT3-ITD.
a single alteration or gene deletions cause FLT3-TKD

How is FLT3 related to AML?

Based on the appearance and gene alterations of the cancer cells, AML is subdivided into subtypes. AMLs with the FLT3 mutation are one of the more aggressive forms and require particular therapies.

The FLT3 gene aids in controlling cell proliferation and survival. Immature blood cells multiply uncontrollably due to the gene mutation.

Because of this, patients with FLT3 mutations have a less favourable prognosis than those with AML of other forms. After therapy, their disease is more likely to recur or relapse. Also, they typically have a poorer survival rate than those who do not have the mutation.

The detection of flt3 mutation

Every person who receives an AML diagnosis should undergo testing for the FLT3 gene mutation, according to recommendations from the American Society of Hematology and the College of American Pathologists.

One of the following tests will be ordered by your doctor:

a blood test Your arm's vein is punctured, and blood is taken and transported to a lab.

bone marrow biopsy or aspiration. Your bone receives a needle insertion. A tiny amount of liquid bone marrow is extracted with the needle.

For flt3 mutation treatment

Chemotherapy was the major form of treatment used up until recently for persons with the FLT3 mutation, but it wasn't very successful in increasing survival rates. The prognosis for those with the mutation is getting better thanks to a new class of medications called FLT3 inhibitors. There are further treatments for the illness being looked into by researchers.

Other therapies

If you have FLT3-mutated AML that is in remission, your doctor might suggest a stem cell transplant (decreased symptoms). It takes stem cells—either from a donor or from you—and injects them into your blood after they have been treated to eliminate leukaemia cells. This might lessen the likelihood of the cancer coming back.