Alpha Thalassemia - HBA1 Gene Sequencing Test Cost & Procedure

Thalassemia alpha A laboratory procedure called HBA1 gene sequencing is performed to identify specifics of the DNA-based HBA1 gene. Alpha-globin protein is made according to instructions from the HBA1 gene. The substance is an essential component of hemoglobin. An HBA1 gene sequencing test may be necessary if you experience symptoms including anemia, pale complexion, weariness, or shortness of breath.

The doctor can determine whether you have healthy or mutated genes by DNA gene sequencing. Alpha thalassemia is a genetic blood condition caused by a mutation in the HBA1 gene. A DNA sample is taken from the skin, cheek cells, hair roots, or blood. Amniotic fluid is taken in the event of fetal DNA analysis. DNA from the sample is taken out, amplified, sequenced, and examined. There is no danger involved and no necessity to make any detailed preparations for the examination.

The alpha-globin protein is made using instructions from the HBA1 gene. This protein is also generated from the HBA2 gene, which is virtually similar. The alpha-globin locus on chromosome 16 contains these two alpha-globin genes, which are situated adjacent to one another.

Alpha-globin is a part (subunit) of hemoglobin, a bigger protein found in red blood cells that transports oxygen to cells and tissues all over the body. Alpha-globin and two other types of globin combine to form the four subunits that make up hemoglobin. Both fofetalemoglobin, which is only active before birth and throughout the newborn stage, and adult hemoglobin, which is active for the remainder of one's life, contain alpha-globin as a component.

Helpful For

• nnnominalalonal alpha thalassemia diagnosis.
• Analysis of a sick individual for non-deletional alpha thalassemia.

An aberrant hemoglobin electrophoresis that led to the discovery of an alpha-globin chain variation was followed up with testing.

Collection Processing Instructions

Whole Blood:

1. To mix the blood, invert several times.

2. Provide the specimen in its original tube.

Extracted DNA from Whole Blood:

1. Indicate the specimen's source and the DNA that was extracted.
2. Deliver the DNA's volume and concentration

Ordering Guidance:

THEV1 / Thalassemia and Hemoglobinopathy Estimation, Serum, and Whole Blood is the first-tier examination for alpha thalassemia marker.

You should order HBEL1 / Hemoglobin Electrophoresis Evaluation, and Blood to perform preliminary testing for an alpha globin variation.

The first-tier genetic test, if genetic testing is needed, evaluates substantial deletional alpha thalassemia mutations. ATHAL / Alpha-Globin Gene Analysis, Varies is obtainable to order.

Necessary Information:

1. The patient's age is necessary.
2. Provide information on recent transfusions.