Alkaline Phosphatase (ALP) Isoenzymes - Book Test at Low Cost

Alkaline Phosphatase (ALP) Isoenzymes

Alkaline Phosphatase (ALP) Bone Isoenzymes

Book Alkaline Phosphatase (ALP) Bone Isoenzymes Appointment Online at the best price in Delhi/NCR from Ganesh Diagnostic. NABL & NABH Accredited Diagnostic centre in Delhi offering a wide range of Radiology & Pathology tests. Get Free Ambulance & Free Sample collection from Home. 24 Hour Open.

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What is the ALP isoenzyme Test?

The Alkaline phosphatase (ALP) is considered to be an enzyme that is naturally present throughout the body. It is seen in many variations in form of the isoenzymes. Each isoenzyme of the ALP is considered to be different, depending on where in the body it’s being produced

The bones make the isoenzyme also called as the ALP-2. The Levels of this enzyme would increase when the bones are said to be growing or the bone cells are active.

An ALP bone isoenzyme test would detect the abnormal levels of bone growth that might be associated with different diseases such as:

  • Paget’s disease 
  • Bone Cancers
  • Osteoporosis
  • Hyperparathyroidism
  • Leukemia

Why is It Done?

The doctor might order an ALP-2 test if the healthcare professional is concerned in case of a bone disease.

Symptoms of this bone disease are as follows:

  • Chronic Bone Disease
  • Joint Pain
  • Brittle Bones
  • Deformed Bones

The ALP-2 test would monitor the bone disease treatment.

What Do Abnormal Levels of ALP Isoenzyme Indicate?

High Levels of ALP Isoenzyme 

The higher levels of Isoenzyme test indicate the following:

  • Osteoblastic Bone Tumors
  • Osteomalacia, or Rickets
  • Osteoporosis
  • Paget’s disease 

Lower Levels of ALP Isoenzymes

The lower levels of Isoenzyme test indicate the following:

  • Hypophosphatasia
  • Malnutrition
  • Hypothyroidism
  • Deficiency of Protein 
  • Wilson Disease
  • Pernicious Anemia
  • Deficiency of Zinc 

Guidelines to Follow Before, During and After the Test

Here are some guidelines an individual can refer to once they have decided to undergo Alkaline Phosphatase Bone isoenzymes 

The required documents needed for this test includes your valid government ID and an appropriate Doctor’s prescription.

A. Before the Test

  1. Nothing Specific to prepare for ALP Bone Isoenzymes in advance.
  2. However, if you consume aspirin or birth control pills, certain antibiotics or estrogen, it is important to inform the doctor, as it may hamper the results 
  3. Usually, Fasting is required (6-12 hours) before the test. 

 B. During the Test

  • During the blood test, the doctor would take the blood sample from the vein in your arm, using the small needle. 
  • Then, a small amount of blood would be drawn and collected into the corresponding test tube or the vial
  • You might feel a little sting when the needle pricks or while it is being removed. This would usually take less than even five minutes.

C. After the Test

There is no specific or special precaution that must be taken post this test.

However, if the result of this test is positive, then further tests may be needed to rule out further conditions. This would be required to determine the type of bone disease the patient is suffering from.

Normal Range in Healthy Individuals

ALP bone isoenzymes normal range for the healthy adults would be 12.1 to 42.7.

Cost of ALP Isoenzymes Test in Delhi

The cost of ALP Isoenzymes in Delhi varies by region and facility. So, constantly get tested at trustworthy diagnostic centers like Ganesh Diagnostic. It is staffed by trained and experienced professionals to assure patient and visitor safety.

The average price for this Test is seen to differ from one center to another. The price is said to be between Rs 5000 to Rs. 8000 in Delhi.

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Frequently Asked Questions

This test is generally used to diagnose or even monitor the following conditions: 

  • Any Bone Disease
  • Liver Disease
  • Gallbladder Disease
  • Bile Duct Disease
  • Pain in the Abdomen

Isoenzymes of the ALP or alkaline phosphatase, it gets separated by the electrophoresis technique on the cellulose acetate, and these were also developed by the gel imprint which is a substrate. The gel was prepared in the alkaline buffer and also contained in β-naphthyl acid phosphate, which will be hydrolyzed to β-naphthyl and also phosphorus.

The isoenzymes present for ALP are: Four Isozymes
The Alkaline phosphatase is seen to be divided into four isozymes depending upon site of the tissue expression which are as follows : Intestinal ALP, Placental ALP, Germ cell ALP and then tissue nonspecific alkaline phosphatase or with liver or bone or kidney (L/B/K) ALP. 

The Bone alkaline phosphatase (ALP) is considered to be an ectoenzyme which is attached to the outer surface of cell membrane of the osteoblasts by the compound - glycosylphosphatidylinositol.

It will be partly released into the bloodstream. The Bone ALP and the liver ALP constitutes for about 95% of the total ALP activity in the human serum.

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