A topoisomerase I inhibitor called irinotecan is used to treat a variety of solid tumor types, most often in conjunction with other chemotherapeutic drugs to treat colorectal cancer. For the treatment of colorectal cancer, irinotecan and 5-fluorouracil (5FU) is frequently utilized. Irinotecan...
A topoisomerase I inhibitor called irinotecan is used to treat a variety of solid tumor types, most often in conjunction with other chemotherapeutic drugs to treat colorectal cancer. For the treatment of colorectal cancer, irinotecan and 5-fluorouracil (5FU) is frequently utilized. Irinotecan and its functional metabolite, SN-38, inhibit topoisomerase I, staving off the re-ligation of single-stranded DNA breaks stimulated during the DNA synthesis phase of cellular replication. Cell death eventually impacts the negligence to effectively restore the resulting double-stranded DNA deterioration.
The most prevalent irinotecan polymorphic variant is identified by the UGT1A1 Genotyping Kit, a PCR-based technique, using allele-specific probes. The testing process consists of three easy steps:
A real-time PCR device is required for the UGT1A1 Genotyping Kit. There are no columns or DNA isolation supplies included.
A rapidly evolving standard oncology procedure is the usage of multi-gene testing media to individualize therapy. A familiar characteristic of multi-gene molecular testing assays is the inclusion of UGT1A1, which encodes for the uridine diphosphate glucuronosyltransferase (UGT) 1A1 enzyme. Multiple medications utilized in oncology may be involved in UGT1A1 polymorphisms' impacts on drug-induced toxicities. But there isn't much information available, and it can vary depending on the source, and on how to incorporate UGT1A1 results into treatment decision-making.. There is a review of available materials that offer suggestions for UGT1A1-guided medicine prescribing, along with suggestions for how to incorporate them into patient care.
|Test Type||Irinotecan Toxicity Genotyping (UGT1A1)|
Irinotecan Toxicity Genotyping (UGT1A1) (Pathology Test)
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